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Efectos secundarios asociados al tratamiento con maraviroc y otros antagonistas de CCR5. Impacto potencial del bloqueo del receptor CCR5
| Content Provider | Semantic Scholar |
|---|---|
| Author | López, José Ramón Arribas |
| Copyright Year | 2008 |
| Abstract | hepatoxicity, no increase in liver toxicity has been demonstrated in patients treated with maraviroc even if they are co-infected by hepatotropic virus. Nor was there any evidence of an increase in the incidence of neoplasms or serious infections in patients treated with maraviroc. In a study on naive patients, maraviroc produced nonsignificant changes in total cholesterol, LDL, HDL and triglycerides. Although CCR5 co-receptors play a role in the immune response of the body, it has not been shown whether individuals homozygote for its deletion (delta-32 mutation) have an increased risk of serious infections, with the possible exception of encephalitis due to the West Nile virus. However, long-term follow up is required on patients treated with to be able to rule out any increased susceptibility to infections or neoplasms. |
| Starting Page | 23 |
| Ending Page | 27 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0213-005X(08)76560-1 |
| Volume Number | 26 |
| Alternate Webpage(s) | https://www.elsevier.es/index.php?p=revista&pRevista=pdf-simple&pii=S0213005X08765601 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0213-005X%2808%2976560-1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
