Loading...
Please wait, while we are loading the content...
Similar Documents
Effect of protease inhibitors in mice treated with the hepatocarcinogen, hexachlorocyclohexane (alpha-isomer) and the bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Arai, Harumi Shirai, Tomoyuki Hananouchi, Motoo Hirose, Masao Murasaki, Gen’i Ito, Nobuyuki |
| Copyright Year | 1978 |
| Abstract | Studies were made on the effect of protease inhibitors (pepstatin, leupeptin, and antipain) on the induction of tumors in mice by the alpha-isomer of 1,2,3,4,5,6-hexachlorocyclohexane (alpha-BHC) and by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Animals were given 0.05% alpha-BHC in the diet or 0.05% BBN in their drinking water and then fed on a powder diet supplemented with 0.1% protease inhibitors. The incidence of liver nodular hyperplasias was significantly higher in the group treated with alpha-BHC and leupeptin than in the group treated with alpha-BIC alone, but pepstatin and antipain did not affect induction of liver nodular hyperplasias by alpha-BHC. None of the three protease inhibitors influenced the induction of bladder tumors by BBN. |
| Starting Page | 1314 |
| Ending Page | 1318 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/cancersci1959/69/4/69_4_593/_pdf |
| PubMed reference number | 81788v1 |
| Volume Number | 69 |
| Issue Number | 4 |
| Journal | Gan |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
