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Inhibition of N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder tumor in rats by alpha-difluoromethylornithine.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kawahara, Motoshi Matsuhashi, Takaaki Yagishita, Tsutomu Tajima, Masataka Matsushima, Matajûro |
| Copyright Year | 1987 |
| Abstract | The therapeutic effects of alpha-difluoromethylornithine (DFMO) on rats with bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) were examined. Eight-week-old male Wistar rats were given 0.05% BBN in their drinking water for a period of 4 weeks. Therapy (0.1% DFMO in their drinking water) was started at week 4 and all rats were killed at week 60. DFMO was seen to significantly reduce the incidence, the mean number and the total size of tumors. No side-effects of DFMO were noted, except alopecia, which started at month 7 of the therapy. |
| Starting Page | 27 |
| Ending Page | 30 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 3107357 |
| Journal | Medline |
| Volume Number | 33 |
| Issue Number | 1 |
| Alternate Webpage(s) | https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/119025/1/33_27.pdf |
| Journal | Hinyokika kiyo. Acta urologica Japonica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |