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[Therapeutic drug monitoring of risperidone and its active metabolite 9-hydroxyrisperidone in the treatment of schizophrenia].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Baymeeva, Natalia V. Platova, Angelina I. Kaleda, V. G. Miroshnichenko, I. I. |
| Copyright Year | 2019 |
| Abstract | AIM To conduct a routine therapeutic drug monitoring (TDM) and analyze its results for the optimization of pharmacotherapy. MATERIAL AND METHODS Fifty-six inpatients (in total 68 samples) with various forms of schizophrenia were enrolled. High performance liquid chromatography with mass-spectrometric detection was used for quantitative determination of risperidone and 9-hydroxyrisperidone in the serum. RESULTS Concentrations of risperidone and 9-hydroxyrisperidone were correlated with drug dose. Total concentrations in the blood at doses from 2 to 8 mg per day were distributed as follows: 44.1% were in the therapeutic, 29.4% in sub-therapeutic (<20 ng/mL) and 26.5% in conditionally toxic range (>60 ng/mL). CONCLUSIONS Concentrations of risperidone and 9-hydroxyrisperidone did not follow the normal distribution. The results showed that monitoring of the total concentration of risperidone and its metabolite 9-hydroxyrisperidone was an effective tool for testing and quality control for the purpose of individualization of pharmacotherapy. |
| Starting Page | 24 |
| Ending Page | 28 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.17116/jnevro201911903124 |
| Alternate Webpage(s) | https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2019/3/downloads/ru/1199772982019031024 |
| PubMed reference number | 31089091 |
| Alternate Webpage(s) | https://doi.org/10.17116/jnevro201911903124 |
| Journal | Medline |
| Volume Number | 119 |
| Issue Number | 3 |
| Journal | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
