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Multiplexing superparamagnetic beads driven by multi-frequency ratchets.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gao, Lu Tahir, Muhammad Akram Virgin, Lawrence N. Yellen, Benjamin B. |
| Copyright Year | 2011 |
| Abstract | Here, we explore the single particle dynamics of superparamagnetic beads exposed to multifrequency ratchets. Through a combination of theory, simulation, and experiment, we determine the important tuning parameters that can be used to implement multiplexed separation of polydisperse colloidal mixtures. In particular, our results demonstrate that the ratio of driving frequencies controls the transition between open and closed trajectories that allow particles to be transported across a substrate. We also demonstrate that the phase difference between the two frequencies controls not only the direction of motion but also which particles are allowed to move within a polydisperse mixture. These results represent a fundamentally different approach to colloidal separation than the previous methods which are based on controlling transitions between phase-locked and phase-slipping regimes, and have a higher degree of multiplexing capabilities that can benefit the fields of biological separation and sensing as well as provide crucial insights into general ratchet behavior. |
| Starting Page | 1 |
| Ending Page | 6 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.mukarramtahir.com/5.pdf |
| PubMed reference number | 22038314v1 |
| Alternate Webpage(s) | https://doi.org/10.1039/c1lc20683d |
| DOI | 10.1039/c1lc20683d |
| Journal | Lab on a chip |
| Volume Number | 11 |
| Issue Number | 24 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bead Dosage Form Greater Integer (number) Numerous Physical object Small mixture non-T, non-B childhood acute lymphoblastic leukemia |
| Content Type | Text |
| Resource Type | Article |
