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Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Beermann, Julia Piccoli, Maria-Teresa Viereck, Janika Thum, Thomas |
| Copyright Year | 2016 |
| Abstract | Advances in RNA-sequencing techniques have led to the discovery of thousands of non-coding transcripts with unknown function. There are several types of non-coding linear RNAs such as microRNAs (miRNA) and long non-coding RNAs (lncRNA), as well as circular RNAs (circRNA) consisting of a closed continuous loop. This review guides the reader through important aspects of non-coding RNA biology. This includes their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system). We specifically focus on non-coding RNAs as potential therapeutic targets and diagnostic biomarkers. |
| Starting Page | 603 |
| Ending Page | 609 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://physrev.physiology.org/content/physrev/96/4/1297.full.pdf |
| PubMed reference number | 27535639v1 |
| Alternate Webpage(s) | https://doi.org/10.1152/physrev.00041.2015 |
| DOI | 10.1152/physrev.00041.2015 |
| Journal | Physiological reviews |
| Volume Number | 96 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biological Markers Biopolymer Sequencing Long Intergenic Non-Protein Coding RNA MicroRNAs Neoplasms Transcript non-T, non-B childhood acute lymphoblastic leukemia non-T, non-B, cALLa negative childhood acute lymphoblastic leukemia |
| Content Type | Text |
| Resource Type | Article |
