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Effects of chronic blockade of NMDA receptors during synaptogenesis on glutamate receptor-mediated currents in cultured hippocampal neurons
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kato, Kenichi Shirao, Tomoaki Takahashi, Hideto Sekino, Yuko |
| Copyright Year | 2007 |
| Abstract | Perineuronal nets (PNNs) consisting of chondroitin sulfate proteoglycans (CSPGs) and hyaluronic acids are known to be associated with distinct neuronal population in mammalian brain. In present study, we examined the function of neuroprotective action of PNNs against amyloid protein (A ) in cultured cortical neurons, and the effect of chondroitinase ABC (ChABC) on Fos expression in GABAergic interneuron in vivo. In vitro study, the application of A to cultured neurons induced apoptosis on PNNs-negative neurons, however, PNNs-positive neurons survived. In vivo study, immobilization stress caused Fos expression in the primary somatosensory cortex (S1). There was no significant difference of total number of Fos-positive neurons in the S1 after ChABC injection, however, double labeling study of Fos and GABAergic interneuron revealed that the percentage of Fos-positive neurons in GABAergic interneurons was fewer than control. These results indicate that PNNs are concerned with neuroprotection against A and neural activity of GABAergic interneuron. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neures.2007.06.852 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0168010207013375 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0168010207013375?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neures.2007.06.852 |
| Volume Number | 58 |
| Journal | Neuroscience Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
