NDLI: Differential effects of chlorpromazine on ionotropic glutamate receptors in cultured rat hippocampal neurons

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Differential effects of chlorpromazine on ionotropic glutamate receptors in cultured rat hippocampal neurons

Content Provider	Semantic Scholar
Author	Żarnowska, Ewa D. Mozrzymas, Jerzy Władysław
Copyright Year	2001
Abstract	The effect of a widely used phenothiazine, chlorpromazine (CPZ) on ionotropic glutamate receptors was investigated using the patch-clamp technique in cultured rat hippocampal neurons. The non-N-methyl-D-aspartate (NMDA) receptors were insensitive to CPZ. The current responses to NMDA showed a wide range of variability of both the rate and the extent of desensitization. The responses characterized by fast and profound desensitization were strongly inhibited by 30 microM CPZ. The effectiveness of block of NMDA responses was clearly correlated with the apparent time constant of the desensitization onset. The extent of desenstitization was found to be increased by CPZ. We conclude that CPZ inhibits the NMDA receptors and propose that the sensibility to CPZ may depend both on the subunit composition and on the state of receptor modulation by intracellular factors.
Starting Page	53
Ending Page	56
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/S0304-3940(01)01809-2
PubMed reference number	11356306
Journal	Medline
Volume Number	305
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394001018092
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394001018092?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0304-3940%2801%2901809-2
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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