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Efficacy of a novel, natural extract of (–)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX, niacin-bound chromium and Gymnema sylvestre extract in weight management in human volunteers: a pilot study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Preuss, Harry G. Bagchi, Debasis Bagchi, Manashi Satyanarayana, Sirasani Dey, Dipak K. |
| Copyright Year | 2004 |
| Abstract | In this pilot study, the efficacy of a novel, natural extract of a highly bioavailable, calciumpotassium salt of (‐)-hydroxycitric acid (HCA-SX) alone and in combination with a niacin-bound chromium (NBC) and Gymnema sylvestraextract (GSE) was evaluated for weight loss in moderately obese subjects by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and serotonin levels, and enhanced excretion of urinary fat metabolites. Garcinia cambogia-derived (‐)-hydroxycitric acid (HCA) has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has shown the ability to restore insulin function, metabolize fat, turn protein into muscle, and convert sugar into energy, which plays a role in appetite regulation and facilitates weight loss. Gymnema sylvestreis a traditional herb that helps to promote weight loss possibly through its ability to reduce cravings for sweets and control blood sugar levels. A randomized, double-blind, placebo-controlled human clinical study was conducted in thirty obese subjects (ages 21-50, BMI26 kg/m 2 ) for eight weeks in Elluru, India. The subjects were randomly divided into three groups (10 subjects/group) and given HCA-SX 4,667 mg (60% HCA providing 2,800 mg HCA/day) (Group A), a combination of HCA-SX 4,667 mg, NBC 4 mg (providing 400 g elemental Cr) and GSE 400 mg (providing 100 mg gymnemic acid) (Group B), or placebo (Group C) daily in 3 equally divided doses 30-60 min before each meal. This |
| Starting Page | 45 |
| Ending Page | 58 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.nutres.2003.09.007 |
| Volume Number | 24 |
| Alternate Webpage(s) | https://garcinia.com/docs/study-1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
