NDLI: Enantioselective synthesis of dialkylated N-heterocycles by palladium-catalyzed allylic alkylation.

Please wait, while we are loading the content...

Enantioselective synthesis of dialkylated N-heterocycles by palladium-catalyzed allylic alkylation.

Content Provider	Semantic Scholar
Author	Numajiri, Yoshitaka Jiménez-Osés, Gonzalo Wang, Bo Houk, Kendall N. Stoltz, Brian M.
Copyright Year	2015
Abstract	The enantioselective synthesis of α-disubstituted N-heterocyclic carbonyl compounds has been accomplished using palladium-catalyzed allylic alkylation. These catalytic conditions enable access to various heterocycles, such as morpholinone, thiomorpholinone, oxazolidin-4-one, 1,2-oxazepan-3-one, 1,3-oxazinan-4-one, and structurally related lactams, all bearing fully substituted α-positions. Broad functional group tolerance was explored at the α-position in the morpholinone series. We demonstrate the utility of this method by performing various transformations on our useful products to readily access a number of enantioenriched compounds.
Starting Page	827
Ending Page	828
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://stoltz2.caltech.edu/publications/169-s-2015.pdf
PubMed reference number	25714704v1
Alternate Webpage(s)	https://doi.org/10.1021/ol503425t
DOI	10.1021/ol503425t
Journal	Organic letters
Volume Number	17
Issue Number	5
Language	English
Access Restriction	Open
Subject Keyword	Alkylation Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone Lactams Palladium carbonyl compound cell transformation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in