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Exercise effects on lung tumor metastases and in vitro alveolar macrophage antitumor cytotoxicity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Davis, John Mark Kohut, Marian L. Jackson, Darryl A. Colbert, Lisa H. Mayer, Eugene Paul Ghaffar, Abdul |
| Copyright Year | 1998 |
| Abstract | This study examined the effects of moderate and prolonged exercise on 1) lung tumor metastases and 2) alveolar macrophage antitumor response in vitro. C57Bl/6 mice were assigned to either Ex-30 (30-min run), Ex-F (run to fatigue), Ex-F-24 h (run to fatigue 24 h before tumor injection), or Con (rested in lanes above the treadmill). Mice received intravenous injections of syngeneic B16 melanoma cells 30 min postexercise. Lungs were removed 7 or 10 days later, and tumor foci were counted. Ex-F had fewer tumors than either Ex-30 or Con, whereas Ex-F-24 h also showed a strong trend toward fewer tumors. The initial localization of tumor cells in the lungs after injection was not different among groups. For the in vitro experiment, mice were killed immediately after exercise or 8 h later. Alveolar macrophages were removed and cultured in vitro with B16 melanoma cells. The growth of the tumors cultured with macrophages from Ex-F was lower than Con after exercise and, to a lesser extent, 8 h later. In Ex-30, this effect was only found immediately after exercise. The data suggest that prolonged exercise has a protective effect on lung tumor metastases and enhances alveolar macrophage antitumor cytotoxicity. |
| Starting Page | R1454 |
| Ending Page | R1459 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpregu.physiology.org/content/ajpregu/274/5/R1454.full.pdf |
| Alternate Webpage(s) | http://ajpregu.physiology.org/content/ajpregu/274/5/r1454.full.pdf |
| PubMed reference number | 29598354v1 |
| Alternate Webpage(s) | https://doi.org/10.1152/ajpregu.1998.274.5.R1454 |
| DOI | 10.1152/ajpregu.1998.274.5.r1454 |
| Journal | American journal of physiology. Regulatory, integrative and comparative physiology |
| Volume Number | 274 |
| Issue Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antitumor Response Fatigue In Vitro [Publication Type] Lung Neoplasms Macrophages, Alveolar Neoplasm Metastasis Non-Small Cell Lung Carcinoma PersonNameUse - assigned Rest Treadmill, device melanoma pediatric intracranial germ cell brain tumor |
| Content Type | Text |
| Resource Type | Article |
