NDLI: Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities

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Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities

Content Provider	Semantic Scholar
Author	Mokni, Meherzia Hamlaoui, Sonia Karkouch, Ines Amri, Mohamed Marzouki, Lamjed Limam, Ferid Aouani, Ezzedine
Copyright Year	2013
Abstract	In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were determined. Data showed that resveratrol improved recovery of post-ischemic ventricular functions when compared to control. Resveratrol also improved myocardial lipoperoxidation, free iron and antioxidant enzyme activities. Resveratrol decreased significantly catalase while it increased peroxidase and superoxide dismutase activities. In this later case, native PAGE analysis of superoxide dismutase isoforms revealed that resveratrol up regulated iron and manganese isoforms. Resveratrol exerted potential cardioprotection partly by its antioxidant properties.
Starting Page	867
Ending Page	875
Page Count	9
File Format	PDF HTM / HTML
DOI	10.22037/ijpr.2013.1404
PubMed reference number	24523766
Journal	Medline
Volume Number	12
Alternate Webpage(s)	http://ijpr.sbmu.ac.ir/article_1404_c17c062f20f1824bbcf0c3191c50aaef.pdf
Alternate Webpage(s)	https://doi.org/10.22037/ijpr.2013.1404
Journal	Iranian journal of pharmaceutical research : IJPR
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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