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Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities.
| Content Provider | Europe PMC |
|---|---|
| Author | Mokni, Meherzia Hamlaoui, Sonia Karkouch, Ines Amri, Mohamed Marzouki, Lamjed Limam, Ferid Aouani, Ezzedine |
| Abstract | In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were determined. Data showed that resveratrol improved recovery of post-ischemic ventricular functions when compared to control. Resveratrol also improved myocardial lipoperoxidation, free iron and antioxidant enzyme activities. Resveratrol decreased significantly catalase while it increased peroxidase and superoxide dismutase activities. In this later case, native PAGE analysis of superoxide dismutase isoforms revealed that resveratrol up regulated iron and manganese isoforms. Resveratrol exerted potential cardioprotection partly by its antioxidant properties. |
| ISSN | 17350328 |
| Journal | Iranian Journal of Pharmaceutical Research : IJPR |
| Volume Number | 12 |
| PubMed Central reference number | PMC3920701 |
| Issue Number | 4 |
| PubMed reference number | 24523766 |
| e-ISSN | 17266890 |
| Language | English |
| Publisher | Shaheed Beheshti University of Medical Sciences |
| Publisher Date | 2013-01-01 |
| Publisher Place | Tehran, Iran |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2013 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services |
| Subject Keyword | Resveratrol Heart Ischemia/reperfusion injury MDA Free iron Catalase Superoxide dismutase Peroxidase Antioxidant enzyme isoforms |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical) |
