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Effects of GABA and l-glutamic acid on the potassium-evoked in vitro release of substance P- and neurokinin A-like immunoreactivities are different in the rat striatum and substantia nigra
| Content Provider | Semantic Scholar |
|---|---|
| Author | Humpel, Christian Saria, Alois |
| Copyright Year | 1989 |
| Abstract | Slices of the rat substantia nigra and striatum were superfused in vitro to measure release of tachykinins (TKs). Potassium (30 and 60 mM) infusion caused a 3- to 10-fold outflow of both substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) in the substantia nigra as well as in the striatum as measured by radioimmunoassay. The potassium-evoked release of SP-LI and NKA-LI was significantly, but not completely (by 25-70%) inhibited by simultaneous perfusion with L-glutamic acid (50 microM) and gamma-aminobutyric acid (GABA, 50 microM) in the substantia nigra. No significant inhibition was, however, observed in the striatum. The present data indicate a differential regulation of tachykinins in the striatum and substantia nigra by L-glutamic acid and GABA. The presynaptic regulation of TK release may therefore differ in the dendritic and terminal region of the striatonigral pathway. |
| Starting Page | 159 |
| Ending Page | 163 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(89)90029-3 |
| PubMed reference number | 2484728 |
| Journal | Medline |
| Volume Number | 105 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394089900293 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394089900293?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2889%2990029-3 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
