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Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sørensen, Gunnar Wörtwein, Gitta Fink-Jensen, Anders Woldbye, David |
| Copyright Year | 2013 |
| Abstract | Several studies have suggested a role for neuropeptide Y (NPY) in addiction to drugs of abuse, including cocaine. Recently, our group showed a role for the NPY Y5 receptor in the modulation of acute reinforcing effects of cocaine using self-administration and hyperlocomotion paradigms. In the present study, we further explored potential anti-addiction-related effects of Y5 antagonism in another murine model of cocaine addiction-related behavior: conditioned place-preference (CPP). Using this model, it was tested whether blockade or deficiency of the NPY Y5 receptor could influence the induction, extinction or reinstatement of a conditioned cocaine response. We found that the Y5 antagonist L-152,804 causes faster extinction and reduced reinstatement of cocaine-induced CPP but did not reduce the ability of cocaine to induce CPP. Similarly, Y5-KO mice displayed faster extinction, and reinstatement of cocaine-induced CPP was absent. The development of CPP for cocaine was similar between Y5-KO and WT mice. Taken together, the present data show that Y5 antagonism attenuates relapse to cocaine addiction-related behavior. Prevention of relapse is considered to be of pivotal importance for the development of an effective treatment against cocaine addiction and therefore Y5 receptors could be a potential future therapeutic target in cocaine addiction. |
| Starting Page | 151 |
| Ending Page | 156 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.pbb.2013.02.010 |
| PubMed reference number | 23454535 |
| Journal | Medline |
| Volume Number | 105 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0091305713000464 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0091305713000464?dgcid=api_sd_search-api-endpoint |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
