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Modulation of stress- and cocaine prime-induced reinstatement of conditioned place preference after memory extinction through dopamine D3 receptor
| Content Provider | Semantic Scholar |
|---|---|
| Author | Guerrero-Bautista, R. Couto, Bruno Ribeiro Do Hidalgo, Juana M. Cárceles-Moreno, Francisco José Milanés, María Victoria |
| Copyright Year | 2019 |
| Abstract | &NA; Accumulating evidence indicates that dopamine (DA) D3 receptor (DAD3R) antagonists appear highly promising in attenuating cocaine reward and relapse in preclinical models of addiction. In the present study, we investigated the effects of the selective DAD3R antagonist SB‐277011‐A on the reinstatement of cocaine‐induced conditioned place preference (CPP) produced by a priming dose of cocaine, by social defeat stress and by two kinds of physiological stressors (restraint and tail pinch) in male adult mice. We also explored reinstatement‐related plasma corticosterone levels (as marker of stress response) and the effects of blocking DAD3R. Administration of SB‐277011‐A (24 or 48 mg/kg i.p.) did not modify conditioned reinstatement of cocaine seeking triggered by cocaine prime. By contrast, we found that the vulnerability to reinstatement of the CPP of defeated animals that have undergone CPP extinction was abolished by the DAD3R antagonist (24 mg/kg) given 30 min before the test session. Reactivation of the CPP response produced by physiological stress stimuli was also attenuated by SB‐277011‐A (48 mg/kg i.p.). On the other hand, the blockade of DAD3R significantly prevented the increased corticosterone release during reinstatement of cocaine‐induced CPP that was seen in social defeated animals, in mice suffering physiological stress and after cocaine prime. Present results demonstrate a modulation by DAD3R of the reactivation of the incentive value of cocaine‐associated cues induced by social and physiological stress stimuli, which was associated to a glucocorticoid‐dependent mechanism. Our results also point to a possible potential therapeutic use of selective DAD3R antagonists for the prevention of stress‐induced cocaine‐seeking and relapse. HighlightsDAD3R is involved in the reinstatement of cocaine‐induced place preference provoked by social and physiological stressful stimuliDAD3R does not participate in the reinstatement of cocaine‐induced place preference provoked by a high dose of the drugDAD3R blockade prevent the increased corticosterone release during reinstatement of cocaine‐induced CPP during stress.Corticosterone release after cocaine prime‐induced reinstatement is not modulated by DAD3R |
| Starting Page | 308 |
| Ending Page | 320 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.pnpbp.2019.01.017 |
| PubMed reference number | 30707990 |
| Journal | Medline |
| Volume Number | 92 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0278584618305712 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0278584618305712?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.pnpbp.2019.01.017 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
