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Mesenchymal stem cells and regenerative medicine: how lipogems technology make them easy, safe and more effective to use
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tremolada, Carlo |
| Copyright Year | 2017 |
| Abstract | MSCs are found as pericytes in all capillaries of all tissues of our body and the concept that fat tissue is an optimal source is now well established [1-5]. MSC of fat (ASCs) are very numerous compared to other tissues [4-8]. Fat tissue is available in most patients and can be easily harvested with a minimally invasive surgical approach, using a blunt cannula and syringe vacuum, offering a highly viable ASC population with optimal differentiation potential that is maintained with aging [3,9-12]. These cells can differentiate in vitro into several cell lineages, such as adipocytes, chondrocytes, osteoblasts, and myoblasts [2-5, 13-19]. In addition, they naturally secrete many bioactive molecules working as a sort of “mini-drugstore” that modulates the local immune response and creates an ideal regenerative environment [20-23]. The use of ASCs, expanded or simply obtained by enzymatic treatment as SVF (Stromal Vascu-lar Fraction), created a huge interest and both in vitro and in vivo studies clearly demonstrated their antiinflammatory and regenerative potentials [24]. Nevertheless, the prolonged ex vivo expansion may in-duce cell senescence, thus leading to clinical results below expectations. In addition, the majority of the proposed techniques have complex regulatory issues [25-29]. In the last few years, we have been facing a significant number of studies aimed at the improvement of the therapeutic effects provided by the traditional fat transfer and structural fat grafting techniques [30-33]. In an effort to optimize this regenerative potential, MSC enrichment techniques, essentially based on enzymatic or mechanical devices, have been proposed [34,35]. In our experience, a minimally manipulated fat tissue is preferable, not only from a regulatory prospective [28,29], but mainly because of the biological rationale. Indeed, mechanically derived MSC versus enzymatically isolated MSC have shown to have better differentiation potential [9, 10], wider secretome36, and a large difference in exosomes contents [22,37,38]. The Lipogems® technology guarantees all of the requirements in an easy, quick, disposable device and represents a very promising “natural” approach in different fields [9, 39-51]. |
| File Format | PDF HTM / HTML |
| DOI | 10.15406/mojbm.2017.02.00047 |
| Volume Number | 2 |
| Alternate Webpage(s) | https://www.istitutoimage.it/wp-content/uploads/2018/06/lipogems-mini-review.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
