NDLI: Mesenchymal stem cells to treat liver diseases.

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Mesenchymal stem cells to treat liver diseases.

Content Provider	Europe PMC
Author	Eom, Young Woo Kang, Seong Hee Kim, Moon Young Lee, Jong In Baik, Soon Koo
Copyright Year	2020
Abstract	Mesenchymal stem cells (MSCs) are being developed for stem cell therapy and can be efficiently used in regenerative medicine. To date, more than 1,000 clinical trials have used MSCs; of these, more than 80 clinical trials have targeted liver disease. MSCs migrate to damaged liver tissues, differentiate into hepatocytes, reduce liver inflammatory responses, reduce liver fibrosis, and act as antioxidants. According to the reported literature, MSCs are safe, have no side effects, and improve liver function; however, their regenerative therapeutic effects are unsatisfactory. Here, we explain, in detail, the basic therapeutic effects and recent clinical advances of MSCs. Furthermore, we discuss future research directions for improving the regenerative therapeutic effects of MSCs.
ISSN	23055839
Volume Number	8
PubMed Central reference number	PMC7347787
Issue Number	8
PubMed reference number	32775364
Journal	Annals of Translational Medicine [Ann Transl Med]
e-ISSN	23055847
DOI	10.21037/atm.2020.02.163
Language	English
Publisher	AME Publishing Company
Publisher Date	2020-04-01
Access Restriction	Open
Rights License	Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0. 2020 Annals of Translational Medicine. All rights reserved.
Subject Keyword	Cell therapy liver disease mesenchymal stem cells (MSCs) regenerative medicine
Content Type	Text
Resource Type	Article
Subject	Medicine

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