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Synthesis of Some Benzofuranyl Thieno[2,3-d] ....... Synthesis of Some Benzofuranyl Thieno[2,3-d] Pyrimidine Derivatives with Biological Interest
| Content Provider | Semantic Scholar |
|---|---|
| Author | Taha, Nadia Mohamed Islam, Enas Marzok, Nermin A. Ali, A. W. Micky, Jehane A. |
| Copyright Year | 2018 |
| Abstract | Interaction of visnaginone or khellinone (1a,b) with cyanoacetamide, ethyl cyanoacetate or molanonitrile and elemental sulfur in presence of triethylamine afforded thiophene enamino derivatives (2a-d) respectively according to Gewald method. Acetylation of 2a with acetic anhydride gave 3. Condensation of 2b with p-chlorobenzaldehyde yielded 4. Compound 6 was afforded from reaction of enamino carboxamide (2b) with thiourea.. Compound 2b reacted with benzoyl chloride to give thienopyrimidine (8). N-phenyl thienopyrimidine (11) and N-amino thienopyrimidine (13) were prepared from reaction of 2c with phenyl isothiocyanate and hydrazinolysis of 12 with hydrazine hydrate. The structures of these compounds were confirmed by infrared, mass and H-NMR spectra. The biological activity of some compounds were discussed and found to be active. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://absb.journals.ekb.eg/article_7549_e1e4c5b651c74dcfb665e54b0f941798.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |