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Synthesis and Cytotoxicity of Thiophene, Thieno[2,3-C]Pyrazole, Thieno[2,3-D]Pyrimidine and Pyridine Derivatives Derived from 2-Acetylfuran
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mohamed, Abeer A. Abouzied, Amr S. Hamed, Faten I. |
| Copyright Year | 2017 |
| Abstract | This work deals with the synthesis and cytotoxicity of some heterocyclic compounds starting from 2-acetylfuran. The title compound was used for the synthesis of thiophene derivative 3 through its reaction with elemental sulfur and ethyl cyanoacetate. Compound 3 was used for the synthesis of thiophene, thieno[2,3-c]pyrazole, thieno[2,3-d]pyrimidine and pyridine derivatives through its reaction with different reagents. The newly synthesized compounds were screened through three cancer cell lines. Compound 13b showed the highest potency among the synthesized compounds. |
| Starting Page | 1 |
| Ending Page | 14 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| DOI | 10.18488/journal.64.2017.51.1.14 |
| Alternate Webpage(s) | http://www.conscientiabeam.com/pdf-files/che/64/IJCMR-2017-5(1)-1-14.pdf |
| Alternate Webpage(s) | https://doi.org/10.18488/journal.64.2017.51.1.14 |
| Volume Number | 5 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
