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Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons
| Content Provider | Semantic Scholar |
|---|---|
| Author | Salgado-Commissariat, Delanthi Alkadhi, Karim A. |
| Copyright Year | 1997 |
| Abstract | The anti-epileptiform effect of serotonin was characterized in cellular models of epilepsy using electrophysiological recording techniques. In the bicuculline model, both serotonin (20 microM) and its 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 10 microM) completely blocked the epileptiform discharge and caused membrane hyperpolarization and reduction in input resistance. These effects were completely antagonized by the 5-HT1A receptor antagonist N-t-butyl-3(4-[2-methoxyphenyl]piperazin-1-yl)-2-phenyl-propanamid e(WAY 100135) (10 microM). Epileptiform discharge induced by positive current injection was also blocked by serotonin. The presence of WAY 100135 renders serotonin ineffective in the same model. In the bicuculline model, epileptiform discharge blocked by serotonin reappeared and was also intensified when BaCl2 was added to the medium. To rule out the possibility of serotonin-induced hyperpolarization strengthening the inhibitory effect of endogenous Mg2+ on glutamate N-methyl-D-aspartic acid (NMDA) receptor we studied the antiepileptic effect of serotonin in the 0 Mg2+ model. Spontaneous activity and evoked bursts seen with the 0 Mg2+ model were completely blocked by serotonin. WAY 100135 completely antagonized serotonin effects in this model as well. This study provides evidence suggesting that in rat CA1 pyramidal neurons, serotonin can inhibit epileptiform activity in a variety of accepted epilepsy cellular models and that inhibition of epileptiform bursts by serotonin may be mediated by activation of the 5-HT1A receptor subtype. |
| Starting Page | 1705 |
| Ending Page | 1712 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0028-3908(97)00134-2 |
| PubMed reference number | 9517442 |
| Journal | Medline |
| Volume Number | 36 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0028390897001342 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0028390897001342?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0028-3908%2897%2900134-2 |
| Journal | Neuropharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
