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Serotonin preferentially hyperpolarizes capsaicin-sensitive C type sensory neurons by activating 5-HT1A receptors
| Content Provider | Semantic Scholar |
|---|---|
| Author | Todorovic, Slobodan M. Anderson, Edmund G. E. |
| Copyright Year | 1992 |
| Abstract | The effects of serotonin (5-HT) were investigated by intracellular recording from 179 dorsal root ganglion (DRG) cells classified by conduction velocity. Bath applied 5-HT depolarized 82% and hyperpolarized 4% of the A-type cells. In C-type cells, 5-HT depolarized only 41%, but hyperpolarized 39% of the cells. The depolarizing responses were of two types; an increase or decrease in R(in), mediated by 5-HT2or3 receptors, respectively. These receptors were observed in both A- and C-type cells. Hyperpolarizing responses were largely confined to A(delta)- and C-type cells. Carboxamidotryptamine and 8-OH-dipropylamino-tetralin were full agonists in eliciting hyperpolarization, and metitepin, spiperone and spiroxitrine behaved as competitive antagonists. This indicated that hyperpolarization was mediated by a 5-HT1A receptor. A 5-HT1A&3 receptor were found co-localized on some C-type cells. A strong depolarizing response to capsaicin was observed in the subgroup of C-type neurons that were also hyperpolarized by 5-HT. Thus a co-localization of capsaicin and 5-HT1A receptors was also observed. |
| Starting Page | 212 |
| Ending Page | 218 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(92)91209-W |
| PubMed reference number | 1511304 |
| Journal | Medline |
| Volume Number | 585 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/000689939291209W |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/000689939291209W?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2892%2991209-W |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
