NDLI: Hémisynthèse de dérivés de l’acide grandiflorénique et évaluation préliminaire de leur activité biologique.

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Hémisynthèse de dérivés de l’acide grandiflorénique et évaluation préliminaire de leur activité biologique.

Content Provider	Semantic Scholar
Author	Tesch, Rios Nahiely, Nurby
Copyright Year	2017
Abstract	Ces travaux de these decrivent l’hemisynthese de derives de l’acide grandiflorenique (AG). Ce produit naturel a dans un premier temps ete converti en ent-kaur-9(11),16-dien-19-ol, compose qui a ensuite ete esterifie dans les conditions de Steglich par une serie d’acides benzoiques diversement substitues. Aux douze nouveaux composes ainsi obtenus a ete ajoutee la synthese du 9(11),16-dien-19-(2- methyl-5-nitro-1H-imidazol-1-yl)ethyl-ent-kaurene. Ces derives de l’AG ont ete soigneusement purifies, puis completement caracterises (IR, SM, RMN 1D et 2D) en vue de leur evaluation biologique. L’activite antibacterienne a ete testee sur differentes souches bacteriennes comme Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa et Escherichia coli. Les proprietes fongicides ont ete evaluees sur Candida albicans et C. krusei. L’activite anti-inflammatoire in vivo a ete etudiee sur des souris BIO:NMRI en utilisant le test de l’oedeme de l’oreille induit par le xylol. Les derives d’acide grandiflorenique n’ont malheureusement montre aucune activite antibacterienne, ni antifongique, mais leur activite anti-inflammatoire s’est montree prometteuse dans le cas de l’inflammation aigue, le 9(11),16-dien-18-[2-(4-isobutylphenyl)propyl]-ent-kaurene se revelant etre le meilleur compose.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://tel.archives-ouvertes.fr/tel-01827248/document
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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