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1-Oxabicyclic beta-lactams as new inhibitors of elongating MPT--a key enzyme responsible for assembly of cell-surface phosphoglycans of Leishmania parasite.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ruhela, Dipali Chatterjee, Patrali Vishwakarma, Ram A. |
| Copyright Year | 2005 |
| Abstract | New iminosugars (1-oxabicyclic beta-lactam disaccharides) have been synthesized as inhibitors of elongating alpha-D-mannosyl phosphate transferase (eMPT), a key enzyme involved in the iterative biosynthesis of cell-surface phosphoglycans of the Leishmania parasite. The design is based on a transition-state model for this remarkable enzyme that transfers intact alpha-D-mannosyl-phosphate from GDP-Man. Since these phosphoglycans are unique to Leishmania and are essential for its infectivity and survival, their biosynthetic pathway has emerged as a novel target for anti-leishmanial drug and vaccine design. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/b4/b418247b/b418247b.pdf |
| PubMed reference number | 15750647v1 |
| Volume Number | 3 |
| Issue Number | 6 |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anabolism Biosynthetic Pathways Chorionic Gonadotropin, beta Subunit, Human Disaccharides Genus: Leishmania Guanosine Diphosphate Host-Parasite Interactions Lactams Transferase alpha-Mannosidosis beta Thalassemia beta-Lactams |
| Content Type | Text |
| Resource Type | Article |
