Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.

Content Provider	Semantic Scholar
Author	Denny, Paul W.
Copyright Year	2005
Abstract	To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the beta-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three beta-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and beta-adaptin1 are constitutively expressed throughout the Leishmania life cycle. Clathrin relocalises in amastigotes relative to promastigotes, consistent with developmental alterations to the morphology of the endo-membrane system.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://fieldlab.org/Reprints_files/Denny%20et%20al%202005.pdf
PubMed reference number	15639137v1
Volume Number	109
Issue Number	1
Journal	Experimental parasitology
Language	English
Access Restriction	Open
Subject Keyword	Adaptor Protein Complex beta Subunits CLTC gene Chorionic Gonadotropin, beta Subunit, Human Clathrin Endometriosis Frame (physical object) Genus: Leishmania Leishmania major Open Reading Frames Reading Frames (Nucleotide Sequence) SLC3A2 gene Tissue membrane adaptin location
Content Type	Text
Resource Type	Article