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Targeting Hypoxia and Angiogenesis through HIF-1 α Inhibition
| Content Provider | Semantic Scholar |
|---|---|
| Author | Díaz-González, Juan A. Russell, James Rouzaut, Ana Gil-Bazo, Ignacio Montuenga, Luis M. |
| Copyright Year | 2006 |
| Abstract | Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1α plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the “angiogenic switch”. HIF-1α contributes to tumor aggressiveness, invasiveness and resistance to radiotherapy and chemotherapy. Targeting HIF-1α is an attractive strategy, with the potential for disrupting multiple pathways crucial for tumor growth. We review recent findings on the potential efficacy of small molecules to downregulate HIF-1α. These promising drugs inhibit HIF-1α synthesis or transcriptional activity by blocking a variety of steps in several different signaling pathways. Blocking HIF-1α activity should not only downregulate tumor angiogenesis, but also interfere with glycolytic metabolism and tumor cell growth. This strategy could also improve the efficiency of established tumor therapies. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dadun.unav.edu/bitstream/10171/18805/1/12diazgonzalez4-10.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
