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Targeting hypoxia and angiogenesis through HIF-1alpha inhibition

Content Provider	Scilit
Author	Diaz-Gonzalez, Juan A. Russell, James Rouzaut, Ana Gil-Bazo, Ignacio Montuenga, Luis
Copyright Year	2005
Description	Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1? plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the “angiogenic switch”. HIF-1? contributes to tumor aggressiveness, invasiveness, and resistance to radiotherapy and chemotherapy. Targeting HIF-1? is an attractive strategy, with the potential for disrupting multiple pathways crucial for tumor growth.. We review recent findings on the potential efficacy of small molecules to down-regulate HIF-1?. These promising drugs inhibit HIF-1? synthesis or transcriptional activity by blocking a variety of steps in several different signaling pathways. Blocking HIF-1? activity should not only down-regulate tumor angiogenesis, but also interfere with glycolytic metabolism and tumor cell growth. This strategy could also improve the efficiency of established tumor therapies.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.10.2195?needAccess=true
Ending Page	1062
Page Count	8
Starting Page	1055
ISSN	15384047
e-ISSN	15558576
DOI	10.4161/cbt.4.10.2195
Journal	Cancer Biology & Therapy
Issue Number	10
Volume Number	4
Language	English
Publisher	Informa UK Limited
Publisher Date	2005-10-27
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Angiogenesis Efficacy Hypoxia Treatments Blocking Tumor Aggressiveness Resistant
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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