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Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cook, Wendy K. Coffman, Robert Alt, Frederick W. |
| Copyright Year | 1988 |
| Abstract | To elucidate the mechanism of IL-4-induced enhancement of IgE and IgG1 production, murine splenic B cells and A-MuLV-transformed cells were cultured with LPS and IL-4 and assayed for epsilon and gamma 1 transcripts. Concomitant treatment with IL-4 and LPS induced expression of C epsilon transcripts in both normal and transformed cells. Expression of these truncated C epsilon transcripts preceded accumulation of normal epsilon mRNA in treated cells. Consistent data were obtained with respect to gamma 1 RNA expression. These results suggest that IL-4 can direct class switching in the context of a mechanism associated with differential expression of germline constant region genes. |
| Starting Page | 2385 |
| Ending Page | 2389 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 3264328 |
| Volume Number | 168 |
| Journal | The Journal of experimental medicine |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/d6/93/je16862385.PMC2189140.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abelson murine leukemia virus Immunoglobulin Class Switching Immunoglobulin E Interleukin-4 Interleukins Spleen Transcript Transcription, Genetic |
| Content Type | Text |
| Resource Type | Article |
