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Cellular level of 8-oxo-2'-deoxyguanosine in DNA does not correlate with urinary excretion of the modified base/nucleoside.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Foksiński, Marek Gackowski, Daniel Różalski, Rafał Olinski, Ryszard |
| Copyright Year | 2003 |
| Abstract | We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base analysed with a recently developed methodology involving HPLC prepurification followed by gas chromatography with isotope dilution mass spectrometric detection. No correlation was found between these markers of oxidative DNA damage commonly used in epidemiological studies. Several possible explanations of this finding are discussed. |
| File Format | PDF HTM / HTML |
| DOI | 10.18388/abp.2003_3708 |
| Alternate Webpage(s) | http://www.actabp.pl/pdf/2_2003/549.pdf |
| Alternate Webpage(s) | http://www.actabp.pl/pdf/2_2003/549s.pdf |
| PubMed reference number | 12833180 |
| Alternate Webpage(s) | https://doi.org/10.18388/abp.2003_3708 |
| Journal | Medline |
| Volume Number | 50 |
| Issue Number | 2 |
| Journal | Acta biochimica Polonica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |