Back ground level of 8-oxo-2 ′-deoxyguanosine in lym pho cyte DNA does not cor re late with the con cen tra tion of an ti ox i dant vi ta mins in blood plasma

Content Provider	Semantic Scholar
Author	Gackowski, Dan Iel Ciecierski, Marek Jawień, Arkadiusz Olinski, Ryszard
Copyright Year	2001
Abstract	An ti ox i dant vi ta mins, be ing effective free rad i cal scav en gers, can pro tect cel lu lar DNA from ox i da tive dam age. Therefore, in the pres ent study we re port on the re la tion ship be tween basal level of 8-oxo-2′-deoxyguanosine in hu man lym pho cyte DNA and the concentration of an ti ox i dant vi ta mins (A, C and E). The av er age level of 8-oxo-2′-deoxyguanosine in lym pho cytes of the stud ied group (15 males and 20 fe males) was 9.57 per 10 dG mol e cules. The en dog e nous level of ascor bic acid (vi ta min C) in the plasma was, on av er age, 56.78 μM, while the mean con cen tra tions of retinol (vi ta min A) and α-tocopherol (vi ta min E) were 1.24 μM and 25.74 μM, re spec tively. No cor re la tions were found be tween in di vid ual 8-oxo-2′-deoxyguanosine lev els in lymphocyte DNA and en dog e nous con cen tra tion of the vi ta mins.
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Language	English
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Resource Type	Article