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Antigenic Diversity and Serotypes of Helicobacter pylori Associated with Peptic Ulcer Diseases
| Content Provider | Semantic Scholar |
|---|---|
| Author | Park, Seon Mee Jung, Hwoon Yong Yang, Suk Kyun Kim, Hae Ryun Min, Young Il |
| Copyright Year | 1998 |
| Abstract | OBJECTIVES Clinical presentation of Helicobacter pylori (H. pylori) infection has marked variation mainly due to the strain diversity and host susceptibility. Although H. pylori is identified as a major risk factor for gastric and duodenal ulcers, the ulcerogenic or pathogenic strain has not been documented yet. The objective of this study was to investigate antigenic types of the ulcerogenic strain of H. pylori. METHODS The sera of 64 patients were tested by Western blot using Helicoblot 2.0 for six major anti-H. pylori antibodies, together with CLO test and histological examination of gastric biopsy tissues. Thirty-five, nine and 20 patients had duodenal ulcer, gastric ulcer and chronic active gastritis, respectively. The antigenic types of H. pylori were analyzed in 54 patients with positive H. pylori infection. In this study, H. pylori was divided into four serotypes according to the presence and absence of CagA and VagA: type I; CagA (+) and VacA(+), type Ia: CagA (+) and VacA(-), type Ib: CagA(-) and VacA(+), and type II: CagA(-) and VacA(-). RESULTS There was no difference in the number of bands for six antigens: 3.2 +/- 1.4, 3.0 +/- 1.2 and 3.1 +/- 1.4 in 35 duodenal ulcer, 7 gastric ulcer and 12 chronic gastritis, respectively. The band with 119 kDa was 90.7%, which was the most common band with the order of 35, 30, 26.5, 89 and 19.5 kDa. Type I, la and Ib were positive in 22.2, 42.6 and 27.8%, respectively, which were significantly higher than type II (p < 0.05). There was no difference in the positive rates of four urease subtypes between the four serotypes. |
| Starting Page | 104 |
| Ending Page | 109 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/67/17/kjim-13-2-104-6.PMC4531945.pdf |
| PubMed reference number | 9735665v1 |
| Volume Number | 13 |
| Journal | The Korean journal of internal medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bands Biopsy of stomach Body tissue Chronic gastritis Document completion status - Documented Duodenal Ulcer Duodenum Eighty Nine Encephalomyelitis, Western Equine Gastric ulcer Helicobacter pylori Hypochlorite Lactic acid Patients Peptic Ulcer Perforation S100A8 gene S100A8 wt Allele Serotype Subtype (attribute) Urease Western Blotting |
| Content Type | Text |
| Resource Type | Article |
