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Controlling the Self-Assembly of Synthetic Metal-Coordinating Coiled-Coil Peptides
| Content Provider | Semantic Scholar |
|---|---|
| Author | Scheib, Kimberly A. |
| Copyright Year | 2019 |
| Abstract | A distinct gap between the fields of peptide-based supramolecular assemblies and metal-organic frameworks (MOFs) exists. Despite recent efforts to explore this area of materials, many metal-directed peptide-based assemblies remain unpredictable, necessitating deeper study to establish robust design principles with which functional materials may be built. The profound unpredictability is not surprising, since peptide-based building blocks are more complex than others which have achieved success in organic and inorganic materials chemistry. The present study attempts to expand and solidify basic design rules for self-assembling metal-directed peptide-based architectures by first exerting control over the assembly of a serendipitously discovered supramolecular lattice. Recent published work has shown coiled-coil peptides containing one or more unnatural solvent-exposed terpyridine (Tpy) side chains can self-assemble to form supramolecular networks in the presence of copper (II) ion. Unexpected was the involvement of glutamic acid (Glu) side chains in the coordination motif (Tpy-Cu2+-Glu). Here, we seek to exert better control over these materials through systematic placement of both Tpy and Glu residues. Results are presented for six designed sequences, including one that manifests a hexagonal net rare in the materials literature. Collectively, these results demonstrate the power of harnessing peptide folding and metal coordination as driving forces for the formation of predictable supramolecular architectures. |
| File Format | PDF HTM / HTML |
| DOI | 10.2210/pdb6oln/pdb |
| Alternate Webpage(s) | http://d-scholarship.pitt.edu/36451/7/Scheib_2019_ETD_Final_rev1.pdf |
| Alternate Webpage(s) | https://doi.org/10.2210/pdb6oln%2Fpdb |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
