NDLI: Assessment of the role of NMDA receptors located in hippocampal CA1 area on the effects of oral morphine dependency on spatial learning and memory in rat

Please wait, while we are loading the content...

Assessment of the role of NMDA receptors located in hippocampal CA1 area on the effects of oral morphine dependency on spatial learning and memory in rat

Content Provider	Semantic Scholar
Author	Pourmoteabed, Abdolreza Nedaei, S. E. Mehrabinasab, E.
Copyright Year	2006
Abstract	Introduction: It has been reported that oral morphine dependency facilitated formation of spatial learning and memory. In the present study the role of NMDA receptors located in hippocampal CA1 area of morphine dependent rats was studied. Methods: Male rats were divided into 4 groups. Two cannulae were stereotaxically implanted bilaterally into the hippocampal CA1 area. After 5 days recovery, animals received morphine sulfate or sucrose for 30 consecutive days in drinking water. Morris water maze (MWM) studies were performed from day 26 to 30. In the above mentioned days, animals received bilateral intrahippocampal CA1 area injection of 3.7μg/0.5μl D,L-AP5 (NMDA receptors antagonist) or 0.5μl saline, 30 min before daily experimentation. Spatial learning and memory parameters were subjected to the analysis of variance (ANOVA). Results: Morphine dependence potentiated spatial learning and memory parameters using MWM. D,L-AP5 could inhibit formation of spatial learning and memory in both control and dependent group. Conclusion: Activation of NMDA receptors located in hippocampal CA1 area is essential for potentiation of spatial learning and memory in morphine dependence rats.
Starting Page	115
Ending Page	123
Page Count	9
File Format	PDF HTM / HTML
Volume Number	10
Alternate Webpage(s)	http://www.phypha.ir/ppj/files/site1/user_files_d87f0d/archive-A-10-110-37-2bbeee7.pdf
Alternate Webpage(s)	http://www.phypha.ir/ppj/browse.php?a_id=249&ftxt=1&sid=1&slc_lang=en
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in