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The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tsien, Joe Z. Huerta, Patricio T. Tonegawa, Susumu |
| Copyright Year | 1996 |
| Abstract | We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories. |
| Starting Page | 1327 |
| Ending Page | 1338 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0092-8674(00)81827-9 |
| PubMed reference number | 8980238 |
| Journal | Medline |
| Volume Number | 87 |
| Alternate Webpage(s) | http://courses.washington.edu/mem553/Tsien1996(CA1NR1KO).pdf |
| Alternate Webpage(s) | http://www.columbia.edu/itc/hs/medical/neuralsci/2003/slides/34_GeneticSlides.pdf |
| Alternate Webpage(s) | https://courses.washington.edu/mem553/Tsien1996(CA1NR1KO).pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0092867400818279 |
| Alternate Webpage(s) | http://tonegawalab.mit.edu/wp-content/uploads/2014/06/192_Cell_Tsien_1996.pdf |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0092867400818279 |
| Alternate Webpage(s) | http://www.ft.uam.es/neurociencia/gonzalo/webpage/pdf(seminars)/hippocampusNMDA.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S0092-8674%2800%2981827-9 |
| Journal | Cell |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
