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La pharmacocinétique clinique des antirétroviraux : de la théorie à la pratique
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sheehan, Nancy L. |
| Copyright Year | 2005 |
| Abstract | Resume Objectif : Decrire le programme de pharmacocinetique clinique des antiretroviraux de Nijmegen, Pays-Bas, tel qu’observe lors de la bourse GlaxoSmithKline 2004. Mise en contexte : Pendant six semaines, j’ai effectue un stage au Centre medical Radboud (Nijmegen, Pays-Bas) afin d’approfondir mes connaissances et mon experience clinique sur la pharmacocinetique clinique des antiretroviraux. Pres de 250 concentrations plasmatiques d’inhibiteurs de la protease et d’inhibiteurs non nucleosidiques de la transcriptase inverse ont ete analysees et interpretees pendant mon sejour. Des rapports d’avis pharmacologique ont ete rediges pour les medecins traitants pour chaque concentration plasmatique. Les prelevements sanguins provenant de centres hospitaliers a travers les Pays-Bas ont ete analyses avec une methode analytique precise et fiable utilisant la chromatographie liquide a haute performance avec detection par rayons ultraviolets. Les concentrations plasmatiques ont ete interpretees a l’aide de rapport de concentration et de quotient inhibiteur genotypique pour les inhibiteurs de la protease et a l’aide de concentrations minimales et maximales visees pour les inhibiteurs non nucleosiques de la transcriptase inverse. Conclusion : Le programme de pharmacocinetique clinique des antiretroviraux a ce centre est hautement efficace, mais il pourrait beneficier d’une collecte de donnees plus exhaustive afin d’individualiser davantage les interpretations et les recommandations d’ajustements posologiques. Abstract Objective : Describe the antiretroviral therapeutic drug monitoring program in Nijmegen, the Netherlands, as observed during the 2004 GlaxoSmithKline scholarship. Context : A six week rotation was completed at the Radboud Medical Centre (Nijmegen, the Netherlands) to expand my antiretroviral therapeutic drug monitoring knowledge and clinical experience. Close to 250 plasma concentrations of protease inhibitors and non-nucleoside reverse transcriptase inhibitors were analyzed and interpreted during this period. Written reports with pharmacological advice were sent to the treating physicians for each plasma concentration. Blood samples originating from various parts of the Netherlands were analyzed with an accurate and reliable analytical method using high-performance liquid chromatography with ultraviolet detection. The protease inhibitors concentrations were interpreted using concentration ratios and genotypic inhibitory quotients, while non-nucleoside reverse transcriptase inhibitors concentrations were interpreted with targeted minimal and maximal concentrations. Conclusion: The antiretroviral therapeutic drug monitoring program at this centre is highly efficient, but could benefit from more extensive data collection in order to further individualize the interpretations and dose adjustment recommendations. Keywords: therapeutic drug monitoring, antiretroviral, concentration ratio, genotypic inhibitory quotient. |
| File Format | PDF HTM / HTML |
| Volume Number | 38 |
| Alternate Webpage(s) | https://pharmactuel.com/index.php/pharmactuel/article/download/562/230 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
