NDLI: Effects of ethanol on chicksin vivo and on chick embryo tibiae in organ culture

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Effects of ethanol on chicksin vivo and on chick embryo tibiae in organ culture

Content Provider	Semantic Scholar
Author	Ramp, Warren K. Murdock, W. C. Gonnerman, Wayne Peng, Tsung-Hung
Copyright Year	2006
Abstract	Hypocalcemia previously reported in rats and dogs following oral administration of ethanol may have been caused by a movement of calcium from blood to bone. This present study was undertaken to determine whether ethanol also causes hypocalcemia in chicks and to investigate the direct effects of ethanol on mineral accretion, glucose metabolism and growth of embryonic chick tibiae in an organ culture system. A high dose of ethanol (6 g/kg body wt) produced hypocalcemia, hypermagnesemia and an elevated hematocrit in chicks. Resultsin vitro were as follows: 1) 5 to 30 μl ethanol/ml medium produced dose-related increases in bone mineral from 58–440%; 2) lactate production was inhibited at all ethanol levels; 3) increased mineral accretion did not occur in ethanol-treated tibiae when iodoacetate was in the medium, but did occur in mechanically disrupted bones exposed to ethanol; and 4) the ethanol response in bone was directly related to the medium phosphate concentration. The results lead to the following conclusions: 1) ethanol has a direct stimulatory effect on bone mineral accretion and an inhibitory effect on bone glucose metabolismin vitro; 2) viable bone cells and an adequate phosphate supply are necessary for the ethanol response, but tissue integrity is not; and 3) the hypocalcemic effect of ethanolin vivo may at least partially result from ethanol-stimulated bone mineral deposition.
Starting Page	195
Ending Page	203
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1007/BF02546683
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF02546683
PubMed reference number	1148882
Alternate Webpage(s)	https://doi.org/10.1007/BF02546683
Journal	Medline
Volume Number	17
Journal	Calcified Tissue Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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