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Caffeine consumption decreases the response to bronchoprovocation challenge with dry gas hyperventilation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Duffy, Patrick E. Phillips, Yancy |
| Copyright Year | 1991 |
| Abstract | OBJECTIVE To determine whether caffeine consumption affects bronchoprovocation challenge (BPC). DESIGN A prospective, double-blind, placebo-controlled, randomized, crossover trial. PATIENTS Eleven nonsmoking men, aged 18 to 42 years, with normal baseline spirometry and evidence of exercise-induced bronchospasm. INTERVENTION On three separate test days, each individual received, in random order, either placebo, 5 mg/kg caffeine, or 10 mg/kg caffeine, and then underwent BPC with eucapnic voluntary hyperventilation (EVH). RESULTS Caffeine (10 mg/kg) significantly reduced bronchoconstriction compared to placebo (p = 0.02). The reduction in bronchoconstriction correlated with the serum level of caffeine (p = 0.014). CONCLUSIONS Caffeine decreases bronchoconstriction due to EVH. Caffeine should be eliminated from diet prior to BPC. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journal.publications.chestnet.org/pdfaccess.ashx?url=/data/journals/chest/21629/1374.pdf |
| PubMed reference number | 2036818v1 |
| Volume Number | 99 |
| Issue Number | 6 |
| Journal | Chest |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bronchial Spasm Bronchoconstriction Bronchospasm, Exercise-Induced Caffeine Cross-Over Studies Patients Selective Mutism Spirometry mg/kg |
| Content Type | Text |
| Resource Type | Article |
