NDLI: Circulating catecholamines in exercise and hyperventilation induced asthma.

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Circulating catecholamines in exercise and hyperventilation induced asthma.

Content Provider	Semantic Scholar
Author	Barnes, Peter J. Brown, Morris Jonathan Silverman, Michael Gordon Dollery, Colin T.
Copyright Year	1981
Abstract	Plasma noradrenaline, adrenaline, and cyclic 3'5' AMP (cAMP) were measured in seven asthmatic patients with known exercise-induced bronchospasm and six matched non-atopic control subjects during a standard treadmill exercise test and then during matched isocapnic hyperventilation. Normal subjects showed a 5.5 fold rise in noradrenaline and a 3.2 fold rise in adrenaline during exercise compared with a 2.1 fold rise in noradrenaline and no significant rise in adrenaline in asthmatics who all developed bronchoconstriction after exercise (mean fall in peak flow rate 28.4 +/- 5.8%). Plasma cAMP rose 1.4 fold in controls but showed no significant rise in asthmatics. This reduced sympatho-adrenal response to exercise in asthmatics is difficult to explain. The failure of circulating catecholamines to rise and stimulate beta adrenoceptors on the mast cell may facilitate the release of bronchoconstrictor mediators. Matched hyperventilation produced bronchospasm in asthmatics (mean fall in peak flow rate 29.0 +/- 4.4%) but no change in catecholamines in either group suggesting that circulating catecholamines have no direct role in exercise-induced bronchospasm but may play a permissive role via the mast cell.
Starting Page	1
Ending Page	6
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://thorax.bmj.com/content/thoraxjnl/36/6/435.full.pdf
PubMed reference number	6274054v1
Volume Number	36
Issue Number	6
Journal	Thorax
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic Receptor Asthma Atopy Bronchial Spasm Bronchoconstriction Bronchoconstrictor Agents Bronchospasm, Exercise-Induced Catecholamines Cyclic GMP Epinephrine Exercise stress test Norepinephrine Patients Treadmill, device beta-adrenergic receptor mast cell
Content Type	Text
Resource Type	Article

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