NDLI: Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.

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Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.

Content Provider	Semantic Scholar
Author	García-Villalba, Rocío Vissenaekens, Hanne Pitart, Judit Romo-Vaquero, María Espín, Juan Carlos Grootaert, Charlotte Selma, María Victoria Raes, Katleen Smagghe, Guy Possemiers, Sam Camp, John Van Tomás-Barberán, Francisco A.
Copyright Year	2017
Abstract	A TWIN-SHIME system was used to compare the metabolism of pomegranate polyphenols by the gut microbiota from two individuals with different urolithin metabotypes. Gut microbiota, ellagitannin metabolism, short-chain fatty acids (SCFA), transport of metabolites, and phase II metabolism using Caco-2 cells were explored. The simulation reproduced the in vivo metabolic profiles for each metabotype. The study shows for the first time that microbial composition, metabolism of ellagitannins, and SCFA differ between metabotypes and along the large intestine. The assay also showed that pomegranate phenolics preserved intestinal cell integrity. Pomegranate polyphenols enhanced urolithin and propionate production, as well as Akkermansia and Gordonibacter prevalence with the highest effect in the descending colon. The system provides an insight into the mechanisms of pomegranate polyphenol gut microbiota metabolism and absorption through intestinal cells. The results obtained by the combined SHIME/Caco-2 cell system are consistent with previous human and animal studies and show that although urolithin metabolites are present along the gastrointestinal tract due to enterohepatic circulation, they are predominantly produced in the distal colon region.
Starting Page	5480
Ending Page	5493
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1021/acs.jafc.7b02049
PubMed reference number	28616977
Journal	Medline
Volume Number	65
Issue Number	27
Alternate Webpage(s)	https://digital.csic.es/bitstream/10261/166564/1/gastroinstrack.pdf
Alternate Webpage(s)	https://doi.org/10.1021/acs.jafc.7b02049
Journal	Journal of agricultural and food chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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