NDLI: Urolithin Metabotypes Can Determine the Modulation of Gut Microbiota in Healthy Individuals by Tracking Walnuts Consumption over Three Days

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Urolithin Metabotypes Can Determine the Modulation of Gut Microbiota in Healthy Individuals by Tracking Walnuts Consumption over Three Days

Content Provider	Semantic Scholar
Author	García-Mantrana, Izaskun Calatayud, Marta Romo-Vaquero, María Espín, Juan Carlos Selma, María Victoria Collado, María Carmen
Copyright Year	2019
Abstract	Walnuts are rich in polyphenols ellagitannins, modulate gut microbiota (GM), and exert health benefits after long-term consumption. The metabolism of ellagitannins to urolithins via GM depends on urolithin metabotypes (UM-A, -B, or -0), which have been reported to predict host responsiveness to a polyphenol-rich intervention. This study aims to assess whether UMs were associated with differential GM modulation after short-term walnut consumption. In this study, 27 healthy individuals consumed 33 g of peeled raw walnuts over three days. GM profiling was determined using 16S rRNA illumina sequencing and specific real-time quantitative polymerase chain reactions (qPCRs), as well as microbial activity using short-chain fatty acids analysis in stool samples. UMs stratification of volunteers was assessed using ultra performance liquid chromatography-electro spray ionization-quadrupole time of flight-mass spectrometry (UPLC-ESI-QTOF-MS) analysis of urolithins in urine samples. The gut microbiota associated with UM-B was more sensitive to the walnut intervention. Blautia, Bifidobacterium, and members of the Coriobacteriaceae family, including Gordonibacter, increased exclusively in UM-B subjects, while some members of the Lachnospiraceae family decreased in UM-A individuals. Coprococcus and Collinsella increased in both UMs and higher acetate and propionate production resulted after walnuts intake. Our results show that walnuts consumption after only three days modulates GM in a urolithin metabotype-depending manner and increases the production of short-chain fatty acids (SCFA).
File Format	PDF HTM / HTML
DOI	10.3390/nu11102483
PubMed reference number	31623169
Journal	Medline
Volume Number	11
Journal	Nutrients
Alternate Webpage(s)	https://digital.csic.es/bitstream/10261/193507/1/urolithin_metabotypes_modulation_gut_microbiota_healthy_individuals_tracking_walnuts_consumption_days.pdf
Alternate Webpage(s)	https://doi.org/10.3390/nu11102483
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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