NDLI: Botulinum toxin in spinal cord injury patients with neurogenic detrusor overactivity

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Botulinum toxin in spinal cord injury patients with neurogenic detrusor overactivity

Content Provider	Semantic Scholar
Author	Cho, Young Sam Kim, Khae Hawn
Copyright Year	2016
Abstract	Evidence for the efficacy and safety of intravesical onabotulinum toxin A (onabotA) injections has led to them being licensed in many countries, including Korea, for the treatment of patients with urinary incontinence due to neurogenic detrusor overactivity (NDO) resulting from spinal cord injury or multiple sclerosis who are refractory or intolerant to anticholinergic medications. OnabotA injections have an inhibitory effect on acetylcholine release for up to 10 months, with a recommended dose of 200 U. OnabotA treatment has a beneficial effect not only on urinary symptoms, but also on quality of life. Several clinical studies have shown onabotA to have better effects than placebo in achieving continence, reducing incontinence episodes, improving urodynamic parameters, and improving health-related quality of life. Urinary tract infections and postvoid residual volume are the most prevalent side effects. In patients with residual volume, clean intermittent catheterization may be necessary. In patients with spinal cord injury or multiple sclerosis, it is recommended to evaluate physical and cognitive function before intravesical onabotA injection to ensure that the patient and caregiver are able to perform catheterization if necessary. Further controlled trials should assess the optimal dose, injection technique, long-term safety of repeated injections, and optimal timing of onabotA treatment in the treatment of NDO.
Starting Page	624
Ending Page	631
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.e-jer.org/upload/jer-12-6-624.pdf
PubMed reference number	5227327
Alternate Webpage(s)	https://doi.org/10.12965/jer.1632874.437
DOI	10.12965/jer.1632874.437
Journal	Journal of exercise rehabilitation
Volume Number	12
Language	English
Access Restriction	Open
Subject Keyword	Acetylcholine Anticholinergic Agents Multiple Sclerosis Neurogenic Urinary Bladder Patients Spinal Cord Injuries Spinal Cord Neoplasms Urinary Incontinence Urinary tract infection Urodynamics
Content Type	Text
Resource Type	Article

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