NDLI: Will repeated botulinum toxin A improve detrusor overactivity and bladder compliance in patients with chronic spinal cord injury?

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Will repeated botulinum toxin A improve detrusor overactivity and bladder compliance in patients with chronic spinal cord injury?

Content Provider	Europe PMC
Author	Chen, Sheng-Fu Kuo, Hann-Chorng
Copyright Year	2020
Abstract	Chronic spinal cord injury (SCI) can induce neurogenic detrusor overactivity (NDO), leading to urinary incontinence and renal damage due to low bladder compliance and high detrusor pressure during the storage and voiding of urine. In 2011, Botox® (onabotulinumtoxinA, botulinum neurotoxin serotype A [BoNT-A]) was approved by the Food and Drug Administration for the treatment of NDO. Intradetrusor injection of BoNT-A has been shown to have clinical utility for the treatment of urinary incontinence, with consequent improvements in quality of life for patients. In the past 20 years, this treatment has been shown to be an effective treatment for patients with SCI refractory to antimuscarinic medication. The present review focused on publications in MEDLINE/PubMed relating to botulinum toxin to evaluate the treatment outcomes of repeated injection of BoNT-A, the mechanisms of action, results of clinical and urodynamic studies, and adverse effects.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8059473&blobtype=pdf
ISSN	10163190
Journal	Tzu-Chi Medical Journal [Tzu Chi Med J]
Volume Number	33
DOI	10.4103/tcmj.tcmj_77_20
PubMed Central reference number	PMC8059473
Issue Number	2
PubMed reference number	33912405
e-ISSN	22238956
Language	English
Publisher	Wolters Kluwer - Medknow
Publisher Date	2020-07-29
Publisher Place	India
Access Restriction	Open
Rights License	This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Copyright: © 2020 Tzu Chi Medical Journal
Subject Keyword	Bladder compliance Botulinum toxin A Detrusor overactivity Spinal cord injury
Content Type	Text
Resource Type	Article
Subject	Medicine

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