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Conformational analysis of r(CGCGCG) in aqueous solution: an A-type double helical conformation studied by two-dimensional nuclear Overhauser effect spectroscopy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Westerink, H. P. Marel, Gijsbert A. Van Der Boom, Jacques H. Van Haasnoot, C. A. |
| Copyright Year | 1984 |
| Abstract | The conformation of the hexanucleoside pentaphosphate r( CGCGCG ) in aqueous solution was studied by circular dichroism, 1H- and 31P-NMR spectroscopy. The base-, H1'- and H2'-proton resonances were assigned by means of 2D-NOE spectroscopy. The base- and H1'-proton chemical shifts were studied as a function of temperature. Proton-proton distances are computed in A- and A'-RNA as well as in A-, B- and Z-DNA. A qualitative interpretation of the observed 2D-NOE intensities shows that r( CGCGCG ) adopts a regular A-type double helical conformation under our experimental conditions. The CD- and 31P-NMR experiments described in this paper are in agreement with this structure both under low- and high-salt conditions. |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/nar/12.10.4323 |
| PubMed reference number | 6728679 |
| Journal | Medline |
| Volume Number | 12 |
| Issue Number | 10 |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/12/10/10.1093/nar/12.10.4323/2/12-10-4323.pdf?Expires=1492620977&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=CGNbbgONVQ8L47gIPPFZbPDSCkvOad3wDRt9w6qglIUNhU1MUuympTdQJib9nCwCqD9-yk1dH0S2wKUQs6kd3idPy0VbYrKEPs66tXHquXCBDOqKNt2ImDUBgKMhBcZDCDxs-W7dS2~EErXXaJkLF-806j3UhLjKU3NqcIS-DmY~erB2UGoff1IrJjaD44xyp281DddqL9k6UBFrlKn4QlacNJr-pynq58M7ocIx~3ylwLWfe6kPInzBrCG9Goiq7i50o5xZ-DGzKttbshUNdHACMrm00i3~jt13VQtYUkGbIY8ApD2FDOlKYGb0dhetulB-jkoH~0HKwhivJImFSw__ |
| Alternate Webpage(s) | https://doi.org/10.1093/nar%2F12.10.4323 |
| Journal | Nucleic acids research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
