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[Effect of IL-10 on the mite antigen-induced IFN-gamma production by peripheral blood lymphocytes from individuals with bronchial asthma].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kawano, Yohei Yoshizawa, Izumi Noma, Takeshi Toyonaka |
| Copyright Year | 1995 |
| Abstract | Interferon-gamma (IFN-gamma) production was dose-dependently suppressed by the addition of Dermatophagoides farinae (Df), mite antigen in peripheral blood mononuclear cells from children with bronchial asthma. By contrast, the levels of IFN-gamma did not change on stimulation with Df antigen in the normal lymphocytes from nonallergic individuals not sensitized with mite. Recombinant interleukin 10 (IL-10), when added to the normal lymphocytes, significantly reduced the production of IFN-gamma. Moreover, the decreased synthesis of IFN-gamma in patients' lymphocytes was inversely up-regulated by the treatment with anti-IL-10 antibody. Taken together, results suggest the regulatory role of IL-10 in the secretion of IFN-gamma in Df antigen-driven immune responses. |
| File Format | PDF HTM / HTML |
| DOI | 10.2177/jsci.18.538 |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/jsci1978/18/5/18_5_538/_pdf/-char/en |
| PubMed reference number | 8564698 |
| Alternate Webpage(s) | https://doi.org/10.2177/jsci.18.538 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 5 |
| Journal | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
