NDLI: Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist

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Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist

Content Provider	Semantic Scholar
Author	Díaz-Mataix, Llorenç Artigas, Francesc Pardo I Celada, P. Alberti
Copyright Year	2006
Abstract	5-HT(1A) receptor agonists increase the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) and DA release in medial prefrontal cortex (mPFC). The mPFC is enriched in 5-HT(1A) receptors and projects to the VTA, where mesocortical dopaminergic neurons originate. We examined whether 5-HT(1A) receptor activation can modulate the activity of mPFC pyramidal neurons projecting to VTA. These were identified by antidromic stimulation from the VTA and were recorded extracellularly in anesthetized rats. The selective 5-HT(1A) agonist BAY x 3,702 (10-80 microg/kg i.v.) increased the firing rate in 14/19 neurons (283 +/- 79%) and reduced the activity of 5/19 neurons (22 +/- 11%), resulting in an overall 2.2-fold increase of the firing rate. Both effects were blocked by the selective 5-HT(1A) antagonist WAY-100635. These results suggest that the increase in dopaminergic activity produced by 5-HT(1A) receptor activation can be driven by an increase in the activity of projection neurons in mPFC.
Starting Page	288
Ending Page	296
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1016/j.euroneuro.2005.10.003
PubMed reference number	16290106
Journal	Medline
Volume Number	16
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0924977X05001458
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0924977X05001458?dgcid=api_sd_search-api-endpoint
Journal	European Neuropsychopharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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