Loading...
Please wait, while we are loading the content...
Similar Documents
Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bender, Kevin J. Allen, Cara B. Bender, Vanessa Anne Feldman, Daniel E. |
| Copyright Year | 2006 |
| Abstract | Whisker deprivation weakens excitatory layer 4 (L4) inputs to L2/3 pyramidal cells in rat primary somatosensory (S1) cortex, which is likely to contribute to whisker map plasticity. This weakening has been proposed to represent long-term depression (LTD) induced by sensory deprivation in vivo. Here, we studied the synaptic expression mechanisms for deprivation-induced weakening of L4-L2/3 inputs and assessed its similarity to LTD, which is known to be expressed presynaptically at L4-L2/3 synapses. Whisker deprivation increased the paired pulse ratio at L4-L2/3 synapses and slowed the use-dependent block of NMDA receptor currents by MK-801 [(5S,10R)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate], indicating that deprivation reduced transmitter release probability at these synapses. In contrast, deprivation did not alter either miniature EPSC amplitude in L2/3 neurons or the amplitude of quantal L4-L2/3 synaptic responses measured in strontium, indicating that postsynaptic responsiveness was unchanged. In young postnatal day 12 (P12) rats, at least 4 d of deprivation were required to significantly weaken L4-L2/3 synapses. Similar weakening occurred when deprivation began at older ages (P20), when synapses are mostly mature, indicating that weakening is unlikely to represent a failure of synaptic maturation but instead represents a reduction in the strength of existing synapses. Thus, whisker deprivation weakens L4-L2/3 synapses by decreasing presynaptic function, similar to known LTD mechanisms at this synapse. |
| Starting Page | 79 |
| Ending Page | 88 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/26/16/4155.full.pdf |
| PubMed reference number | 16624936v1 |
| Volume Number | 26 |
| Issue Number | 16 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomical maturation Cerebral cortex Depressive disorder Dizocilpine Maleate Intrinsic drive Long-Term Synaptic Depression N-Methyl-D-Aspartate Receptors N-Methylaspartate Pyramidal Cells Strontium Synapses Transmitter Device Component Vibrissae synapse maturation |
| Content Type | Text |
| Resource Type | Article |
