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Estimating the distribution of synaptic reliabilities.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huang, Emily P. Stevens, Charles F. |
| Copyright Year | 1997 |
| Abstract | Using whole cell recording from CA1 hippocampal pyramidal neurons in slices, we examined the progressive decrease of N-methyl-D-aspartate receptor-mediated synaptic responses in the presence of the open-channel blocker MK-801. Previous studies analyzing this decrease have proposed that hippocampal synapses fall into two distinct classes of release probabilities, whereas studies based on other methods indicate a broad distribution of synaptic reliabilities exists. Here we derive the theoretical relationship between the MK-801-mediated decrease in excitatory postsynaptic current amplitudes and the underlying distribution of synaptic reliabilities. We find that the MK-801 data are consistent with a continuous distribution of synaptic reliabilities, in agreement with studies examining individual synapses. In addition, changes in the MK-801-mediated decrease in response size as a consequence of altering release probability are consistent with this continuous distribution of synaptic reliabilities. |
| Starting Page | 2137 |
| Ending Page | 2142 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jn.physiology.org/content/jn/78/6/2870.full.pdf |
| PubMed reference number | 9405507v1 |
| Volume Number | 78 |
| Issue Number | 6 |
| Journal | Journal of neurophysiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aspartic Acid CA1 field Class Dizocilpine Maleate Estimated Excitatory Postsynaptic Currents Hippocampus (Brain) N-Methyl-D-Aspartate Receptors N-Methylaspartate Postsynaptic Current Probability Pyramidal Cells Synapses |
| Content Type | Text |
| Resource Type | Article |
