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Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Hai Cao, Zhi-Ran |
| Copyright Year | 2014 |
| Abstract | Purpose: To investigate the protective effects of (-)-epicatechin on lipopolysaccharide (LPS)-induced inflammation in Raw 264.7 murine macrophages and the possible underlying mechanisms. Methods: The effects of epicatechin on LPS-stimulated production of inflammatory mediators in Raw 264.7 cells were evaluated by enzyme-linked immunosorbent assay. Results: Epicatechin in doses of 5, 25 and 50 µM remarkably (p < 0.05) inhibited the production of proinflammatory mediators including nitric oxide (NO) and prostaglandin E2 (PGE 2), as well as the production of pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in LPS-induced Raw 264.7 macrophages. Conclusion: The results suggest that epicatechin can inhibit inflammatory response and may be a potential therapeutic candidate for the treatment of chronic inflammatory diseases. |
| Starting Page | 1415 |
| Ending Page | 1419 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.4314/tjpr.v13i9.6 |
| Volume Number | 13 |
| Alternate Webpage(s) | https://www.tjpr.org/vol13_no9/2014_13_9_6.pdf |
| Alternate Webpage(s) | https://doi.org/10.4314/tjpr.v13i9.6 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |