NDLI: Prognostic Significance of Survivin and Caspase-3 Immunohistochemical Expression in Patients with Diffuse Large B-cell Lymphoma Treated with Rituximab and CHOP

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Prognostic Significance of Survivin and Caspase-3 Immunohistochemical Expression in Patients with Diffuse Large B-cell Lymphoma Treated with Rituximab and CHOP

Content Provider	Semantic Scholar
Author	Mitrović, Zdravko Ilić, Ivana Aurer, Igor Kinda, Sandra Bašić Radman, Ivo Dotlić, Snježana Ajduković, Radmila Labar, Boris
Copyright Year	2010
Abstract	Survivin is an inhibitor of apoptosis whose expression may be associated with inferior outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated without rituximab. Caspase-3 is the final caspase of the apoptotic cascade and its pattern of expression may also be related to patients' outcome. In this study we investigated immunohistochemical expression of survivin and caspase-3 (CPP32) in 57 patients with DLBCL treated with rituximab and CHOP (R-CHOP). According to previously published criteria, we separately analyzed correlation of different types of survivin expression with patients' outcome. Nuclear survivin was expressed in only 26% of cases, cytoplasmic survivin was expressed in 81% of cases while application of immunoreactivity scoring system yielded 58% of survivin positive cases. Caspase-3 was expressed in 77% of cases. There were no significant correlations between any type of survivin expression and response to treatment or survival of the patients. The expression of caspase-3 was also not associated with patients' outcome. We conclude that survivin and caspase-3 have no significant prognostic significance in patients with DLBCL treated with R-CHOP.
Starting Page	243
Ending Page	247
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1007/s12253-010-9304-4
PubMed reference number	20853074
Journal	Medline
Volume Number	17
Alternate Webpage(s)	http://bib.irb.hr/datoteka/538015.survivin_i_kaspaza.pdf
Journal	Pathology & Oncology Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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