Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma.

Content Provider	Europe PMC
Author	Choi, Soyeon Lee, Yoo Jin Choi, Yunsuk Kim, Misung Kim, Hyun-Jung Kim, Ji Eun Oh, Sukjoong Chae, Seoung Wan Cha, Hee Jeong Jo, Jae-Cheol
Copyright Year	2022
Abstract	BackgroundThe aim of the present study was to evaluate the prognostic significance of B-cell lymphocyte kinase (BLK) expression for survival outcomes in diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP.MethodsWe retrospectively analyzed the medical records of 89 patients from two tertiary referral hospitals. The expression of BLK, SYK, and CDK1 were evaluated in a semi-quantitative method using an H-score, and the proportions of BCL2 and C-MYC were evaluated.ResultsA total of 89 patients received R-CHOP chemotherapy as a first-line chemotherapy. The expression rates of BLK in tumor cells was 39.2% (n = 34). BLK expression status was not significantly associated with clinical variables; however, BLK expression in tumor cells was significantly associated with the expression of both C-MYC and BCL2 (p = .003). With a median follow-up of 60.4 months, patients with BLK expression had significantly lower 5-year progression-free survival (PFS) and overall survival rates (49.8% and 60.9%, respectively) than patients without BLK expression (77.3% and 86.7%, respectively). In multivariate analysis for PFS, BLK positivity was an independent poor prognostic factor (hazard ratio, 2.208; p = .040).ConclusionsHere, we describe the clinicopathological features and survival outcome according to expression of BLK in DLBCL. Approximately 39% of DLBCL patients showed BLK positivity, which was associated as a predictive marker for poor prognosis in patients who received R-CHOP chemotherapy.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9510039&blobtype=pdf
ISSN	23837837
Journal	Journal of Pathology and Translational Medicine [J Pathol Transl Med]
Volume Number	56
DOI	10.4132/jptm.2022.07.26
PubMed Central reference number	PMC9510039
Issue Number	5
PubMed reference number	36128864
e-ISSN	23837845
Language	English
Publisher	The Korean Society of Pathologists/The Korean Society for Cytopathology
Publisher Date	2022-09-13
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2022 The Korean Society of Pathologists/The Korean Society for Cytopathology
Subject Keyword	large B-cell lymphoma Immunohistochemistry
Content Type	Text
Resource Type	Article
Subject	Histology Pathology and Forensic Medicine